A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/55 (2006.01) A61K 9/20 (2006.01) A61K 9/22 (2006.01) A61K 31/16 (2006.01) A61K 31/165 (2006.01) A61K 31/40 (2006.01) A61K 31/4045 (2006.01) A61K 31/41 (2006.01) A61K 31/4164 (2006.01) A61K 31/5513 (2006.01)
Patent
CA 2209714
A controlled release, oral, solid, pharmaceutical composition for a reduced daily dosage regimen is described where the therapeutic ingredient is a poorly soluble basic drug. The formulation comprises the use of a water-soluble alginate salt, a complex salt of alginic acid and an organic carboxylic acid in admixture with the therapeutic drug. A particular embodiment comprising a once a day dosage form for clarithromycin is also described.
La présente invention concerne une composition pharmaceutique orale solide, à libération contrôlée, destinée à un schéma posologique à dose quotidienne réduite, quand le constituant thérapeutique est un médicament basique peu soluble. Cette formulation comprend l'utilisation d'un alginate soluble, un sel complexe d'acide alginique et d'un acide carboxylique organique en mélange avec le médicament thérapeutique. L'invention concerne aussi un mode de réalisation particulier comprenant une forme de dosage à libération une fois par jour pour la clarithromycine.
Broad Neville W.
Carmody Alan F.
Feely Liam C.
Withers Brian C.
Abbott Laboratories
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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