G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/48 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2440409
A detailed three-dimensional structure of rifampicin bound to a core bacterial RNA polymerase (Rif-RNAP) is provided. Crystals of the Rif-RNAP are also included in the invention. The present invention further provides procedures for identifying agents that can inhibit bacterial proliferation through the use of rational drug design predicated on the crystals and crystallographic data disclosed.
L'invention porte sur une structure tridimensionnelle détaillée de rifampicine liée à une polymérase d'ARN bactérienne à noyau (Rif-RNAP). L'invention porte également sur des cristaux de Rif-RNAP. La présente invention porte en outre sur des procédés visant à identifier des agents qui peuvent inhiber la prolifération bactérienne grâce à une élaboration rationnelle de substances thérapeutiques basée sur des cristaux et sur des données cristallographiques.
Campbell Elizabeth
Darst Seth
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
The Rockefeller University
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