A device and a process for aseptic mixing of liquid products

Details A device and a process for aseptic mixing of liquid products A device and a process for aseptic mixing of liquid products

B - Operations, Transporting

01

F

B01F 3/08 (2006.01) A61J 1/00 (2006.01) A61J 1/20 (2006.01)

Patent

CA 2184249

The invention relates to an apparatus for mixing aseptically three or more liquid products (51, 53, 55) and includes at least two pointed connection devices (1, 21, 41) which are provided with through-passing flow passageways (3, 4, 24, 25, 43, 44) and are connected in series by means of a connecting line (61) and are intended to be inserted through closure means (58, 59, 60) of product containers (52, 54, 56). A first of these connection devices (1) functions to place the first container (52) in communication with the surroundings via a sterilizing filter (7), and connects the first container with the second container (54) through the connecting line (61), wherein the product containers are mutually connected together successively by means of respective subsequent connection devices down to the last product container (56) in line in which the final mixture of products, including the product (55), is collected. A subpressure prevails in the last container in line, this subpressure constituting the force by means of which the products are driven through the system. The invention also relates to a connection device (21) and to a system for aseptically mixing three or more liquid products, and also to a method of mixing the products. The invention is primarily intended for application when mixing the liquid components of a preparation for parenteral nutrient supply.

L'invention concerne un appareil pour le mélange aseptique de trois produits liquides (51, 53, 55) ou plus qui comporte au moins deux dispositifs de raccordement pointus (1, 21, 41) dotés de deux passages d'écoulement traversants (3, 4, 24, 25, 43, 44) et raccordés en série au moyen d'une ligne de raccordement (61). Ces dispositifs de raccordement (1, 21, 41) sont destinés à être insérés dans des moyens de fermeture pénétrables (58, 59, 60) de récipients (52, 54, 56) à produit. Un premier dispositif de raccordement (1) permet de mettre le premier récipient (52) en communication avec le milieu ambiant par l'intermédiaire d'un filtre de stérilisation (7) et de le raccorder au second récipient (54) au moyen de la ligne de raccordement (61). Les récipients à produit sont raccordés successivement entre eux, en ligne, au moyen de dispositifs de raccordement respectifs, jusqu'au dernier récipient (56) dans lequel le mélange final de produits, y compris le produit (55), est recueilli. Le dernier récipient en ligne est sous pression négative, laquelle constitue la force au moyen de laquelle les produits sont acheminés dans le système. L'invention porte également sur un dispositif de raccordement (21) et un système pour le mélange aseptique de trois produits liquides ou plus, ainsi que sur un procédé de mélange de ces derniers. Le procédé et l'appareil selon l'invention sont principalement destinés au mélange de composants liquides d'une préparation destinée à être administrée de manière parentérale.

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