A device structure for iontophoresis

A - Human Necessities – 61 – N

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A61N 1/30 (2006.01) A61N 1/32 (2006.01)

Patent

CA 2208336

An iontophoretic device structure of the dissolution-on-use type is provided, wherein an ionized drug is transdermally or transmucosally administered into a living body. The device structure comprises (a) a non-polarizable electrode, (b) a hydrophilic, polymeric gel layer dispersing an ion exchange resin which is able to specifically inhibit the movement of ions dissolved out from the electrode being in use, and (c) a drug layer retaining a drug in a dry condition in a drug retaining membrane, wherein when said device is in use, said drug layer is brought into contact with said hydrophilic, polymeric gel layer so that said drug in the dry condition is dissolved. A humectant may be contained in the hydrophilic, polymeric gel layer and/or the drug layer.

Un système pour l'iontophérèse de type dissolution par utilisation, où un médicament ionisé est administré de manière transdermique ou transmuqueuse dans un corps vivant. Le système consiste en (a) une électrode non polarisée, (b) une couche de gel hydrophile et polymérique dispersant une résine échangeuse d'ions capable particulièrement d'empêcher le mouvement des ions dissous à partir de l'électrode utilisée et (c) une couche médicamenteuse retenant un médicament à l'état sec dans une membrane renfermant des médicaments, où lorsque le système est utilisé, la couche médicamenteuse entre en contact avec la couche de gel hydrophile et polymérique de façon à ce que le médicament à l'état sec soit dissous. Un humectant peut être contenu dans une couche de gel hydrophile et polymérique et (ou) la couche médicamenteuse.

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