G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/543 (2006.01) C07K 1/22 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2203142
The disclosed invention relates to assays for detecting and quantifying A.beta. peptide, using solid supports that are coated with heavy metal cations, such as zinc (II) or copper (II) form of a nitriloacetic acid. Further, diagnostic kits are described which are used to carry out the assays of the present invention. An improvement in an assay for detection of A.beta. peptide is suggested which comprises forming a heavy metal cation/solid support complex. The preferred heavy metal cations for this improvement are zinc (II) or copper (II) form of a nitriloacetic acid. Finally, methods and kits for bulk purification of Aa peptides from biological fluids are taught.
L'invention concerne des dosages permettant de détecter et de quantifier le peptide A beta à l'aide de supports solides qui sont revêtus de cations de métaux lourds tels que la forme zinc (II) ou cuivre (II) d'un acide nitriloacétique. En outre, l'invention concerne des kits diagnostiques qui sont utilisés pour effectuer les dosages de la présente invention. Une amélioration du dosage de l'invention en vue de détecter le peptide A beta consiste à former un complexe cation de métal lourd/support solide. Les cations de métaux lourds préférés pour cette amélioration sont la forme zinc (II) ou la forme cuivre (II) d'un acide nitroloacétique. Enfin, des procédés et des kits pour la purification massive des peptides A beta dans des fluides biologiques sont également décrits.
Bush Ashley I.
Moir Robert D.
Tanzi Rudolph E.
Borden Ladner Gervais Llp
The General Hospital Corporation
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