G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/574 (2006.01) C07K 16/30 (2006.01) G01N 33/577 (2006.01)
Patent
CA 2048998
43 ABSTRACT OF THE DISCLOSURE The present invention involves a method for detecting bladder cancer in a subject. The method preferably comprises firs collecting urine sample from the subject. The presence of a proteinaceous substance having a molecular weight of about 180 kDa according to its relative electrophoretic migration rate through detergent-containing polyacrylamide gel is then measured. This substance reversibly binds concanavalin A and is complexed with gamma globulin while in the urine. The gamma globulin complex binds to Staphylococcal protein A. Said proteinaceous substance, when present in detectable amount, is an indicator of bladder cancer. The method of the present invention for diagnosing bladder cancer in a subject may also be described as comprising detection in a urine sample from said subject of a proteinaceous substance having a molecular weight of about 180 kDa and being unreactive with antibodies specifically binding to carcinoembryonic antigen or epidermal growth factor receptor. When an antibody is used for the present method of diagnosis, an initial step for preparing an antibody specifically bonding a urinary 180 kDa antigen present in urine of bladder cancer victims is carried out. This antibody of course may be prepared by others and merely obtained by commercial purchase. In any case said antibody may be used to detect the bladder cancer-specific 180 kDa antigen of present invention in patient urine. This antibody is most preferably monoclonal or may be polyclonal. H:\UTFC\105\PATAPP.FOR
Babaian Richard J.
Zhau Haiyen E.
Blake Cassels & Graydon Llp
The Board Of Regents Of The University Of Texas System
LandOfFree
A diagnostic protein marker for bladder cancer does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with A diagnostic protein marker for bladder cancer, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and A diagnostic protein marker for bladder cancer will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1745375