A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/30 (2006.01) A61K 47/34 (2006.01) A61K 47/48 (2006.01) A61M 31/00 (2006.01)
Patent
CA 2613355
A method for delivering a drug depot of a compound of interest to a selected region in a subject. The method comprises administering a composition directly to said region of interest, the composition comprising the compound of interest to be delivered (such as an antiinflammatory agent or a chemotherapeutic agent) and a polymer (such as an elastin-like peptide or ELP) that undergoes an inverse temperature phase transition, so that a sustained release of the compound of interest at the selected region is provided. Compositions useful for carrying out the invention are also described.
Ce procédé d'administration d'un dépôt de médicament d'un composé d'intérêt à une région sélectionnée chez un malade consiste à administrer une composition directement à la région d'intérêt, laquelle composition comprend le composé d'intérêt à administrer, un agent anti-inflammatoire ou un agent chimiothérapeutique, et un polymère (un peptide de type élastique ou ELP) subissant une transition de phase à température inverse de sorte que la libération du composé d'intérêt dans la région sélectionnée se prolonge. On prévoit aussi des compositions servant à la préparation de l'invention.
Betre Helawe
Chilkoti Ashutosh
Dreher Matthew R.
Kraus Virginia B.
Setton Lori A.
Duke University
Sim & Mcburney
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