C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/81 (2006.01) C07K 14/81 (2006.01) C12N 9/60 (2006.01) C12N 15/62 (2006.01) C12N 15/67 (2006.01) C12N 15/80 (2006.01)
Patent
CA 2166684
A DNA construct comprising the following sequence: 51-P-SP-(LP)n-PS-HP-31 wherein P is promoter sequence, SP is a DNA sequence encoding the yeast aspartic protease 3 (YAP3) signal peptide, LP is a DNA sequence encoding a leader peptide, n is 0 or 1. PS is a DNA sequence encoding a peptide defining a yeast processing site, and HP is a DNA sequence encoding a polypeptide which is heterologous to a selected host organism. The YAP3 signal peptide provides efficient secretion of heterologous proteins in yeast.
Structure d'ADN comportant la séquence: 5'-P-SP-(LP)n-PS-HP-3' dans laquelle P représente une séquence promoteur, SP représente une séquence d'ADN codant le peptide signal de protéase aspartique de levure 3 (YAP3), LP représente une séquence d'ADN codant un peptide chef de file, n vaut 0 ou 1, PS représente une séquence d'ADN codant un peptide définissant un site de traitement de levure, et HP représente une séquence d'ADN codant un polypeptide hétérologue à un organisme hôte choisi. Le peptide signal de YAP3 assure une sécrétion efficace de protéines hétérologues dans la levure.
Christiansen Lars
Petersen Jens G. Litske
Mccarthy Tetrault Llp
Novo Nordisk A/s
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