C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01) A61K 31/7088 (2006.01) A61K 48/00 (2006.01) C07H 21/00 (2006.01) C07H 21/04 (2006.01) C07K 14/81 (2006.01) C12N 9/22 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2483007
The present invention provides DNAzymes and ribozymes that specifically cleave PAI-1-encoding mRNA. The present invention also provides antisense oligonucleotides that specifically inhibit translation of PAI-1-encoding mRNA. The invention also provides various methods of inhibiting the expression of PAI-1, and methods of treating diseases by such. Finally the invention provides pharmaceutical compositions containing the instant DNAzymes, ribozymes, antisense oligonucleotides, or other inhibitors of PAI-1 expression as active ingredients.
L'invention concerne des ADNzymes et des ribozymes qui clivent spécifiquement un ARNm codant pour PAI-1. L'invention concerne également des oligonucléotides antisens inhibant spécifiquement une translation d'un ARNm codant pour PAI-1. L'invention concerne en outre des méthodes variées permettant d'inhiber l'expression de PAI-1 et des méthodes permettant de traiter des maladies induites par PAI-1. L'invention concerne enfin des compositions pharmaceutiques contenant les DNAzymes, ribozymes, oligonucléotides antisens et autres inhibiteurs de l'expression des PAI-1 utilisées comme ingrédients actifs.
Norton Rose Canada S.e.n.c.r.l.,s.r.l./llp
The Trustees Of Columbia University In The City Of New York
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