C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/87 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) C07K 7/02 (2006.01) C07K 7/60 (2006.01) C07K 14/00 (2006.01) C07K 14/11 (2006.01) C07K 14/775 (2006.01) C12N 5/10 (2006.01) C12N 15/10 (2006.01)
Patent
CA 2131620
2131620 9318759 PCTABS00025 A DNA transporter system capable of non-covalently binding to DNA and facilitating the insertion of the DNA into a cell. The DNA transporter system includes a binding complex which non-covalently binds the DNA. The binding complex includes a molecule that is capable of non-covalently binding to the DNA and being covalently linked to a surface ligand and to a nuclear ligand. The surface ligand is capable of binding to a cell surface receptor and the nuclear ligand is capable of recognizing and transporting the transporter system through the nuclear membrane. A plurality of these binding complexes are attached to the DNA to facilitate the transport of the DNA into the cell. Additionally, a third binding complex which includes a virus can also be non-covalently linked to the DNA. The virus facilitates the movement of the DNA through the cytoplasm and into the nucleus. Also described are a variety of structures which can be used as part of the transporter system as well as methods of using the transporter system to introduce DNA into cells.
Smith Louis C.
Sparrow James T.
Woo Savio L. C.
Baylor College Of Medicine
Smart & Biggar
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