A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/439 (2006.01) A61K 9/19 (2006.01) A61P 9/06 (2006.01) C07D 471/08 (2006.01)
Patent
CA 2315375
The present invention relates to dried preparations containing a class III antiarriythmic compound in the form of crystalline or amorphous salt or any combination thereof, where the counterion is selected from pharmaceutically acceptable water-soluble organic or inorganic acids. The present invention also relates to frozen preparations containing a class III antiarrhythmic coumpound in the form of salt solution, where the counterion is selected from pharmaceutically acceptable water-soluble organic or inorganic acids. Preferred preparations contain a salt of the compound 3,7-diazabicyclo[3.3.1]- nonane-3-carboxylic acid, 7-[(2S)-3-(4-cyanophenoxy)-2-hydroxypropyl]-1,1- dimethylethyl ester (Compound A). Further aspects of the present invention include salts of Compound A per se, processes for preparing the preparation, as well as use of the preparations for prophylaxis and/or treatment of cardiac arrhythmia.
L'invention concerne des préparations séchées contenant un composé anti-arythmisant de la classe III sous forme de sel cristallin ou amorphe ou leur combinaison quelconque, le contre-anion étant choisi parmi des acides organiques ou inorganiques pharmaceutiquement acceptables, solubles dans l'eau. L'invention concerne également des préparations congelées contenant un composé anti-arythmisant de la classe III sous forme de solution saline, le contre-anion étant choisi parmi des acides organiques ou inorganiques pharmaceutiquement acceptables, solubles dans l'eau. Des préparations préférées contiennent un sel du composé 3,7-diazabicyclo[3.3.1]-nonane-3-acide carboxylique, 7-[(2S)-3-(4-cyanophénoxy)-2-hydroxypropyl]-1,1-dimenthyléthyl ester (composé A). D'autres aspects de l'invention incluent des sels du composé A per se, des procédés d'élaboration de ces préparations, et des méthodes d'utilisation de ces préparations à des fins de prophylaxie ou de traitement de l'arythmie cardiaque.
Bjore Annika
Granath Anna-Karin
Astrazeneca Ab
Fetherstonhaugh & Co.
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