A drug active on the central nervous system, a process for...

Details A drug active on the central nervous system, a process for... A drug active on the central nervous system, a process for...

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/505 (2006.01)

Patent

CA 2160717

- 16 - A DRUG ACTIVE ON THE CENTRAL NERVOUS SYSTEM, A PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CON- TAINING IT. The agent is the compound 3-{2-[4-(6-fluoro- benzo[d]isoxazol-3-yl)-3,6-dihydro-2H-pyridin-1-yl]-ethyl}-2- methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one having the formula (I) Image I and pharmaceutically acceptable salts thereof; the process is based on the reduction of a selected pyridin salt by means of a metal borohydride; its preferred application is as an antipsychotic agent.

L'agent est le composé 3-{2-[4-(6-fluoro-benzo[d]isoxazol-3-il)-3,6-dihydro-2H-pyridine-1-il]-éthyle}-2-méthyle-6,7,8,9-tétrahydropyrido[1,2-a]pyrimidine-4-one ayant la formule (I), et ses sels pharmaceutiquement acceptables; le procédé se base sur la réduction d'un sel déterminé de pyridine au moyen d'un borohydrure métallique; de préférence, il peut être appliqué comme antipsychotique.

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