A drug composition for treating tumor with polymeric micelle...

A - Human Necessities – 61 – K

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Details

A61K 47/30 (2006.01) A61K 9/00 (2006.01) C08G 63/91 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2759060

This present disclosure relates to pharmaceutical compositions for treating tumors using a polymeric micelle encapsulating an anti-tumor drug. The polymeric micelle comprises block copolymers comprising at least one hydrophilic block, at least one hydrophobic block, and at least one zwitterion. The present disclosure also relates to methods of enhancing the solubility of such drugs, methods of increasing the blood circulating time of such drugs, and methods of delivering such drugs to one or more solid tumors.

L'invention concerne une composition de médicament pour le traitement d'une tumeur et un procédé permettant d'améliorer la solubilité et le temps de circulation sanguine des antinéoplastiques ainsi qu'un procédé permettant d'administrer le médicament à un ou à plusieurs types de tumeurs solides. Ladite composition comprend au moins une micelle polymère et au moins un agent antinéoplastique encapsulé dans la micelle. La micelle polymère comprend un copolymère à blocs, ce dernier comprenant au moins un polymère hydrophile, au moins un polymère hydrophobe, et au moins un zwitterion. Le procédé consiste en l'administration de la composition de médicament.

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