A drug delivery device and a method of making such device

Details A drug delivery device and a method of making such device A drug delivery device and a method of making such device

A - Human Necessities

61

K

A61K 47/36 (2006.01) A61K 9/20 (2006.01)

Patent

CA 2139747

ABSTRACT OF THE DISCLOSURE A drug delivery device comprising a polymer matrix and a drug contained in or surrounded by the matrix which polymer matrix is a cross-linked hydrogel matrix comprising a dextranase degradable polymer and a cross-linking agent providing covalent bonded network linkage between the polymer chains. The device is suitable for delivering drug to the colon. A method of making the device comprising: (a) dissolving a dextranase degradable polymer in a solvent; (b) adding a cross linking agent capable of cross-linking the polymer with covalent bonds to the solution; (c) allowing the cross-linking agent to react with the dextranase degradable polymer to provide a cross-linked hydrogel matrix, and loading the drug into said solution before or after the reaction between the polymer and the cross-linking agent has finished.

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