C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
195/1.235, 195/1
C12N 15/00 (2006.01) C07K 14/39 (2006.01) C12N 15/10 (2006.01) C12N 15/81 (2006.01) C12P 19/34 (2006.01) C12P 21/02 (2006.01)
Patent
CA 1240940
a-FACTOR AND ITS PROCESSING SIGNALS ABSTRACT OF THE DISCLOSURE Novel DNA constructs are provided for efficient expression of polypeptides by yeasts. The constructs employ yeast a-factor secretion leader and processing signals joined to a DNA sequence encoding a polypeptide of interest in reading frame with the a-factor signals. The constructions provide for the expression, secretion and maturation of the desired polypeptide. A strategy is provided for the isolation of the a-factor secretion leader and processing signals and the joining, by means of a relatively short adaptor, molecules of the DNA sequence encoding the polypeptide to the processing signals in proper reading frame. The bacterial cell strain E. coli HB101 (pAB163) was deposited at the A.T.C.C. on April 20, 1983 and given Accession No. 39342.
450210
Chiron Corporation
Fetherstonhaugh & Co.
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