A factor viii-polypeptide with factor viii:c-activity

Details A factor viii-polypeptide with factor viii:c-activity A factor viii-polypeptide with factor viii:c-activity

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/37 (2006.01) C07K 14/705 (2006.01) C07K 14/755 (2006.01) C12P 21/02 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2349468

The invention relates to a factor VIII-polypeptide with factor VIII:C- activity, which comprises a modification in the A3 and/or C1 and/or C2 domains of the light chain. The factor is characterized in that the modification influences the affinity to binding to a low density lipoprotein receptor protein (LRP). The invention also relates to a method for producing said factor.

L'invention concerne un polypeptide de facteur VIII présentant une activité de facteur VIII:C, qui comporte une modification au niveau des domaines A3 et/ou C1 et/ou C2 de la chaîne légère et qui se caractérise en ce que cette modification influe sur l'affinité de liaison à une protéine de récepteur de lipoprotéines de basse densité (LRP). L'invention concerne également un procédé de production de ce polypeptide.

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