A family of genes encoding apoptosis-related peptides,...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 15/62 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2266325

An isolated polynucleotide at leat 60 % homologous to SEQ ID NO: 1, 3, 5 or 18 encoding a SARP polypeptide; vectors comprising a polynucleotide sequence encoding at least 11 consecutive amino acids of .alpha.SARP polypeptide; a host cell transformed with an isolated polynucleotide or vector; antibodies specific for SARP and use of such polynucleotides and antibodies in diagnostic and therapeutic method. Therapeutic uses of antibodies and polynucleotides of sarp. Methods for treating diseases related to the regulation of SARP expression in tissue and bodily fluid samples, including cancers.

Polynucléotide isolé homologue au moins à 60 % des numéros d'identification de séquence: 1, 3, 5 ou 18, codant un polypeptide de la famille SARP; vecteurs renfermant une séquence polynucléotidique qui code au moins 11 acides aminés consécutifs d'un polypeptide .alpha.SARP; cellule hôte transformée par un vecteur ou un polynucléotide isolé; anticorps propres à la famille SARP, et utilisation desdits polynucléotides et desdits anticorps dans un procédé diagnostique et thérapeutique. On décrit enfin des utilisations thérapeutiques des anticorps et des polynucléotides de sarp et différents procédés pour traiter les maladies liées à la régulation de l'expression SARP dans des échantillons de tissus et de liquides biologiques, y compris certains types de cancers.

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