A fibrin/fibrinogen-binding conjugate

Details A fibrin/fibrinogen-binding conjugate A fibrin/fibrinogen-binding conjugate

C - Chemistry, Metallurgy

07

K

C07K 14/00 (2006.01) C07K 14/745 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2423492

A fibrin/fibrinogen binding conjugate for forming a depot for the sustained release of a pharmaceutically active substacne from a fibrin clot. The conjugate comprises a fibrin/fibrinogen binding moiety bound to a pharmaceutically active substance either directly or via an intervening substance capturing moiety such as an antibody. The conjugate can also be a recombinant fusion protein comprising a fibrin/fibrinogen binding moiety such as VEGF185 C-terminal domain fused to a wound-healing substance such as leptin.

L'invention concerne un conjugué de liaison de fibrine/fibrinogène servant à former un dépôt destiné à la libération soutenue d'une substance active sur le plan pharmaceutique à partir d'un caillot de fibrine. Le conjugué comprend une fraction de liaison de fibrine/fibrogène liée à une substance active pharmaceutiquement, directement ou par l'intermédiaire d'une substance d'intervention capturant ladite fraction comme un anticorps. Ledit conjugué peut également être une protéine de fusion recombinante renfermant une fraction de liaison de fibrine/fibrogène, telle qu'un domaine à extrémité carboxylique VEGF¿185? fusionné à une substance de guérison de blessures, telle que la leptine.

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