A formulation for the buccal transmucosal administration of...

Details A formulation for the buccal transmucosal administration of... A formulation for the buccal transmucosal administration of...

A - Human Necessities

61

K

A61K 47/10 (2006.01) A61K 31/4178 (2006.01)

Patent

CA 2747846

The invention provides a formulation for transmucosal administration of at least one active ingredient from the setron family, the formulation comprising said active ingredient in base form and/or in salt form, a hydroalcoholic solution titrating at least 30° alcohol, and optionally a pH correcting agent, said active principle being present in the state of stable and complete dissolution in the hydroalcoholic solution. The invention also provides a method of preparing this formulation and its use for the treatment and prevention of major nausea and/or vomiting syndromes, and also for the treatment and prevention of digestive spasms.

L'objet de l' invention est une formulation pour l'administration par voie trans-muqueuse d'au moins un principe actif de la famille des Sétrons, constituée dudit principe actif sous forme base et/ou sous forme de sel, une solution hydroalcoolique titrant au moins 30° d'alcool, et éventuellement un agent correcteur de pH, ledit principe actif étant présent en état de dissolution stable et complète dans la solution hydroalcoolique. L'invention se rapporte également à un procédé de préparation de cette formulation et à son utilisation pour le traitement et la prévention des syndromes nauséeux et/ou émétiques majeurs, ainsi que pour le traitement et la prévention des spasmes digestifs.

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