A functional assay of high-density lipoprotein

Details A functional assay of high-density lipoprotein A functional assay of high-density lipoprotein

G - Physics

01

N

G01N 33/92 (2006.01) A61K 48/00 (2006.01) C07H 21/02 (2006.01) C07H 21/04 (2006.01) C12Q 1/42 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/573 (2006.01)

Patent

CA 2404000

This invention provides novel assays that are prognostic and/or diagnostic for atherosclerosis or risk of atherosclerosis. It was discovered that high density lipoprotein (HDL) or components thereof can prevent the oxidation of lipids (e.g. lipids present in LDLs) and can also repair (reduce) already oxidized lipids and thereby reduce the inflammatory response associated with and characteristic of atherosclerotic plaque formation. Moreover it was a discovery of the invention that individuals vary in the ability of their HDL to afford such protection. Thus an assay of HDL protective and/or repair activity provides a highly effective assay for risk of atherosclerosis and its associated pathologies and such assays are provided herein.

Cette invention a trait à de nouveaux dosages servant à établir un pronostic ou un diagnostic en matière d'athérosclérose ou de risque d'athérosclérose. Il a été établi que des lipoprotéines haute densité (HDL) ou leurs composants peuvent empêcher l'oxydation des lipides (par exemple, des lipides présents dans des lipoprotéines à faible densité (LDL)), et peuvent également réparer (réduire) des lipides déjà oxydés et, partant, atténuer la réaction inflammatoire associée à la formation d'une plaque athérosclérotique et caractéristique de celle-ci. Il a été, en outre, découvert que l'aptitude des HDL à conférer une telle protection varie selon les personnes. De la sorte, le dosage selon l'invention, relatif à l'activité protectrice et/ou réparatrice des HDL, constitue une source de renseignement des plus satisfaisante en matière de risque d'athérosclérose ainsi que de pathologies associées.

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