C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/31 (2006.01) A01N 63/04 (2006.01) A61K 38/16 (2006.01) C07K 14/37 (2006.01) C07K 14/38 (2006.01) C12N 1/15 (2006.01) C12N 1/19 (2006.01) C12N 1/21 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2139837
A DNA construct comprising a DNA sequence encoding an antifungal polypeptide, which sequence comprises the nucleo- tide sequence shown in SEQ ID No. 1 or an analogue thereof, which i) hybridizes with a DNA sequence comprising the nucleo- tide sequence shown in SEQ ID No. 1, or with a probe hybridizing with the nucleotide sequence SEQ ID No. 1, ii) encodes a pol- ypeptide which reacts with an antibody reactive with at least one epitope of the polypeptide having the amino acid sequence shown in SEQ ID No. 2, and/or iii) encodes a polypeptide having the amino acid sequence shown in the appended SEQ ID No. 2 or a sequence homologous thereto, provided that the DNA sequence is different from one which encodes the polypeptide hav- ing the amino acid sequence shown in SEQ ID No. 2 except for an asparagine in position 4, an alanine in position 24, a lysine in position 32, a phenylalanine in position 42 and a tyrosine in position 50. The antifungal polypeptide encoded by the DNA con- struct may be used for combating or controlling fungal infections, in particular on plants.
Halkier Torben
Hansen Mogens T.
Lange Lene
Mikkelsen Jan M.
Nielsen Birte A.
Mccarthy Tetrault Llp
Novo Nordisk A/s
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