A fusion protein comprising an interleukin-1 receptor...

Details A fusion protein comprising an interleukin-1 receptor... A fusion protein comprising an interleukin-1 receptor...

C - Chemistry, Metallurgy

07

K

C07K 19/00 (2006.01) A61K 31/56 (2006.01) A61K 38/17 (2006.01) A61K 47/48 (2006.01) A61P 9/10 (2006.01) A61P 19/02 (2006.01) A61P 29/00 (2006.01) A61P 35/02 (2006.01) C07K 14/435 (2006.01) C07K 16/46 (2006.01) C12P 21/02 (2006.01) A61K 39/395 (2006.01)

Patent

CA 2539273

A fusion protein comprising an interleukin-1 receptor antagonist (IL-1ra) with all or part of a constant domain of a heavy or light chain of human immunoglobulin at the carboxy-terminus is disclosed. The fusion protein exhibits a therapeutic effect on inflammation and is useful for treating IL-1 mediated inflammatory diseases, particularly diseases of the joint.

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