A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/70 (2006.01) A61K 9/48 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2642479
The present invention provides a gastro-retentive delivery assembly (GRDA) comprising a folded multi-layered device comprising a macromolecule-containing compartment bordered by enveloping layers and one or more enforcing strips, the device being adapted to unfold when in a subject's stomach, whereupon unfolding, the macromolecule is released from said device via at least one aperture in an enveloping layer. The invention also provides a method for gastroretentive delivery of macromolecules via the GRDA of the invention; a method of preparing the GRDA of the invention as well as the use of GRDA for the manufacture of a medicament for treating a subject for a pathological condition.
La présente invention concerne un assemblage de livraison par rétention gastrique (ALRG) comprenant un appareil multi-couches replié qui comprend un compartiment contenant une macromolécule encadré de couches enveloppantes et une ou plusieurs bandelettes de renforcement, l'appareil étant adapté pour se déplier dans l'estomac d'un sujet, après quoi la macromolécule est libérée dudit appareil par au moins une ouverture dans une couche enveloppante. L'invention concerne également une méthode d'administration par gastro-rétention de macromolécules au moyen de l'ALRG de l'invention ; une méthode pour préparer l'ALRG de l'invention ainsi que l'utilisation de l'ALRG pour fabriquer un médicament pour traiter un sujet souffrant d'une pathologie.
Afargan Michel
Cohen Marina
Kirmayer David
Kluev Lena
Lapidot Noa
Intec Pharma Ltd.
Smart & Biggar
LandOfFree
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