A gene encoding a multidrug resistance human p-glycoprotein...

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 15/12 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12N 15/10 (2006.01) C12N 15/11 (2006.01) C12N 15/63 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2411101

The invention relates to an MDR family P-glycoprotein located on human chromosone 7p15-21, polynucleotide sequences encoding this P-glycoprotein and fragments thereof. This gene is utilized in methods for assessing cancer cell susceptibility to therapies directed against multidrug resistance, and for the design of diagnostic and therapeutic methods relating to cancer multidrug resistance. The invention also relates to methods for determining whether a test compound may inhibit multidrug resistance.

L'invention concerne une P-glycoprotéine de la famille MDR située sur le chromosome humain 7p15-21, des séquences polynucléotidiques codant pour cette P-glycoprotéine et des fragments de cette dernière. Ce gène est utilisé dans des méthodes d'évaluation de la réceptivité de cellules cancéreuses à des thérapies dirigées contre la résistance pléïotrope, et dans la conception de méthodes diagnostiques et thérapeutiques liées à la résistance pléïotrope du cancer. L'invention concerne également des méthodes permettant de déterminer si un composé test peut inhiber la résistance pléïotrope.

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