A gene therapy system and method using alpha-msh and its...

Details A gene therapy system and method using alpha-msh and its... A gene therapy system and method using alpha-msh and its...

A - Human Necessities

01

N

A01N 43/04 (2006.01) A61K 31/70 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) C12N 15/00 (2006.01) C12N 15/09 (2006.01) C12N 15/63 (2006.01) C12N 15/70 (2006.01) C12N 15/74 (2006.01) C12N 15/85 (2006.01) C12N 15/87 (2006.01)

Patent

CA 2406755

Disclosed in this specification is the use alpha-MSH and/or its derivatives as an adjunct to gene therapy. In one aspect, the gene therapy vector includes nucleic acids that expresses alpha-MSH and/or its derivatives. Inflammatory or immune response gene promoter may control the expression of alpha-MSH and/or its derivatives. The sequences may also be expressed together with a therapeutic gene using an internal ribosomal entry site sequence. In another aspect, pharmacologically effective amount of alpha-MSH and/or its derivatives may be administered before, after, or concurrently with the gene therapy vector carrying the appropriate gene.

L'invention concerne l'utilisation de alpha-MSH et/ou ses dérivés comme appoint à une thérapie génique. Dans un mode de réalisation, le vecteur de thérapie génique comprend des acides nucléiques qui expriment alpha-MSH et/ou ses dérivés. Un promoteur génique de réponse immune ou inflammatoire peut réguler l'expression de alpha-MSH et/ou de ses dérivés. Les séquences peuvent également être exprimées en même temps qu'un gène thérapeutique utilisant une séquence de site d'entrée ribosomique interne. Dans un autre mode de réalisation, une dose pharmacologiquement efficace de alpha-MSH et/ou de ses dérivés peut être administrée avant, après ou en même temps que le vecteur de thérapie génique transportant le gène approprié.

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