C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 21/08 (2006.01) C12N 5/0784 (2010.01) C12N 5/00 (2006.01) C12N 5/16 (2006.01) C12P 21/00 (2006.01) C12Q 1/02 (2006.01) G01N 33/15 (2006.01)
Patent
CA 2652086
This invention relates to an in vitro method of producing antigen specific B cells and antibodies that provides for the capture of an entire primary human antibody repertoire for any foreign antigen, allows for screening large numbers of immunogen/adjuvant combinations, and permits the isolation of human monoclonal antibodies on demand thereby obviating the need to immunize humans with the target antigen.
La présente invention concerne un procédé in vitro permettant de produire des lymphocytes B et des anticorps spécifiques à des antigènes, ledit procédé permettant de représenter la capture d'un répertoire entier d'anticorps humains primaires correspondant à n'importe quel antigène étranger; ledit procédé permet également de cribler un grand nombre de combinaisons immunogène/adjuvant et d'isoler à la demande des anticorps monoclonaux humains, ce qui évite de devoir immuniser les êtres humains à l'aide de l'antigène cible.
Guan Yongjun
Lewis George K.
Kirby Eades Gale Baker
University Of Maryland - Biotechnology Institute
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