C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07K 7/04 (2006.01) C07K 14/46 (2006.01) C07K 14/47 (2006.01) C12N 15/10 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2495794
There is provided a method of identifying candidate nucleic acid sequences encoding antimicrobial peptides. The method comprises: identifying an initial peptide of interest; identifying genomic DNA encoding the initial peptide; identifying a flanking sequence on each side of the initial peptide; obtaining primers complementary to the flanking sequences; and, screening a wide range of nucleic acid sequences to identify candidate sequences capable of being amplified using the primers from step e). In some instances the antimicrobial peptide is a hepcidin or a pleurocidin.
L'invention concerne un procédé destiné à identifier des séquences d'acides nucléiques candidates codant des peptides antimicrobiens. Ce procédé consiste: à identifier un peptide initial d'intérêt; à identifier l'ADN génomique codant le peptide initial; à identifier une région flanquante de chaque côté du peptide initial; à obtenir des amorces complémentaires aux régions flanquantes; et, à cribler une gamme étendue de séquences d'acides nucléiques en vue d'identifier des séquences candidates capables d'être amplifiées au moyen des amorces de l'étape e). Dans certaines circonstances, le peptide antimicrobien est une hepcidine ou une pleurocidine.
Douglas Susan
Gallant Jeffrey
Patrzykat Aleksander
National Research Council Of Canada
Sim & Mcburney
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