A glycopeptide and preparation thereof

Details A glycopeptide and preparation thereof A glycopeptide and preparation thereof

C - Chemistry, Metallurgy

07

K

C07K 9/00 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2406953

The stereospecific synthesis of a glycopeptide using a triply orthogonal protection scheme is described, in particular, the synthesis of N- acetylglucosaminyl-.beta.-(1,4)-N-acetylmuramylmonopeptide and derivatives thereof. The glycopeptide is useful for the preparation of N- acetylglulosaminyl-N-acetylmuramyl-L-alanyl-D-isoglutamine and related compounds having a glucosaminyl-.beta.-(1,4)-N-acetylmuramic acid disaccharide core.

L'invention concerne la synthèse stéréospécifique d'un glycopeptide faisant appel à un schéma de protection triplement orthogonal, et en particulier la synthèse d'un monopeptide de N-acétylglucosaminyl-.beta.-[1,4]-N-acétylmuramyle et de dérivés de celui-ci . Ce glycopeptide est utile pour la préparation de GMDP et de composés similaires comprenant une partie centrale disaccharide d'acide glucosaminyl-.beta.-[1,4]-N-acétylmuramique.

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