C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 237/44 (2006.01) A61K 31/165 (2006.01) A61K 31/21 (2006.01) A61K 31/255 (2006.01) A61P 31/12 (2006.01) C07C 229/54 (2006.01) C07C 233/12 (2006.01) C07C 303/26 (2006.01) C07C 307/02 (2006.01) C07C 327/16 (2006.01) C07D 239/52 (2006.01)
Patent
CA 2738256
A group of amino substituted benzoyl derivatives, their preparation and their use. The screening and research on an antiviral drug with hA3G/Vif as a target point proves that the 3-amino benzoyl derivatives not only have inhibiting the combined activity for the hA3G/Vif, but also have a function of inhibiting replication of viruses. The present invention provides the possible breakthrough progress for the problem of HIV drug resistance, thereby providing a novel clinical antiviral drug which has higher efficiency.
Dérivés amino substitués du benzoyle, leur procédé de préparation et leurs applications. Le criblage et la recherche portant sur les médicaments antiviraux sur le hA3G/Vif ont prouvé non seulement l'action inhibitrice des dérivés de 3-amino benzoyle sur l'activité du hA3G/Vif, mais aussi leur utilité dans l'inhibition dans la réplication virale. La présente invention, en proposant un nouveau médicament clinique antiviral de grande efficacité, constitue une possible avancée décisive dans contre la pharmacorésistance du VIH.
Cen Shan
Jiang Jiandong
Li Yanping
Li Zhuorong
Xu Jian
Institute Of Medicinal Biotechnology Chinese Academy Of Medical Science S.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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