A hepatitis c virus codon optimized non-structural ns3/4a...

A - Human Necessities – 61 – K

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A61K 39/29 (2006.01) A61K 48/00 (2006.01) C07K 14/18 (2006.01) C12N 15/40 (2006.01) C12N 15/85 (2006.01) C12N 15/86 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2506820

Aspects of the present invention relate to the creation of a codon-optimized hepatitis C virus (HCV) NS3/4A gene. Embodiments include said NS3/4A gene, fragments of said gene, HCV peptides encoded by said nucleic acids, nucleic acids encoding said HCV peptides, antibodies directed to said peptides, compositions containing said nucleic acids and peptides, as well as methods of making and using the aforementioned compositions including, but not limited to, diagnostics and medicaments for the treatment and prevention of HCV infection.

Selon certains aspects, cette invention concerne la production d'un gène NS3/4A du virus de l'hépatite C (VHC) à codons optimisés. Dans certains modes de réalisation, l'invention concerne ledit gène, des fragments de ce gène, des peptides du VHC codés par lesdits acides nucléiques, des acides nucléiques codant pour les peptides du VHC, des anticorps dirigés contre lesdits peptides, des compositions renfermant lesdits acides nucléiques et peptides, ainsi que des méthodes d'obtention et d'utilisation des compositions susmentionnées, avec notamment, mais pas uniquement, des techniques diagnostiques et des médicaments pour le traitement et la prévention de l'infection par le VHC.

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