A hepatitis c virus non-structural ns3/4a fusion gene

Details A hepatitis c virus non-structural ns3/4a fusion gene A hepatitis c virus non-structural ns3/4a fusion gene

C - Chemistry, Metallurgy

12

N

C12N 15/40 (2006.01) A61K 31/713 (2006.01) A61K 39/29 (2006.01) C07K 14/08 (2006.01) C12N 5/10 (2006.01) C12N 9/50 (2006.01) C12N 15/62 (2006.01) C12N 15/63 (2006.01)

Patent

CA 2618429

Aspects of the present invention relate to the creation of mutant hepatitis C virus (HCV) NS3/4A genes encoding proteins with altered protease activity. Embodiments include said NS3/4A genes, HCV peptides encoded by said nucleic acids, nucleic acids encoding said HCV peptides, antibodies directed to said peptides, compositions containing said nucleic acids and peptides, as well as methods of making and using the aforementioned compositions including, but not limited to, diagnostics and medicaments for the treatment and prevention of HCV infection.

Dans certains aspects, l'invention a trait à la création de gènes NS3/4A mutants du virus de l'hépatite C (VHC), qui codent pour des protéines dotées d'une activité protéase altérée. Dans ses modes de réalisation, la présente invention concerne lesdits gènes NS3/4A, des peptides VHC codés par des acides nucléiques, des acides nucléiques codant pour lesdits peptides VHC, des anticorps dirigés contre lesdits peptides, des compositions contenant lesdits acides nucléiques et peptides, ainsi que des procédés de préparation et d'utilisation desdites compositions, et notamment, mais de façon non limitative, des méthodes diagnostiques et des médicaments destinés à traiter et à prévenir l'infection par le VHC.

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