A homogeneously coated device having osteoinductive and...

A - Human Necessities – 61 – L

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Details

A61L 27/34 (2006.01) A61L 24/02 (2006.01) A61L 24/10 (2006.01) A61L 27/12 (2006.01) A61L 27/22 (2006.01) A61L 27/40 (2006.01) A61L 27/54 (2006.01)

Patent

CA 2466947

The present invention relates to a device having osteoinductive and osteoconductive properties in vivo comprising a carrier containing calcium phosphate and an osteoinductive protein, wherein said carrier is homogenously coated with said protein. Moreover, the present invention relates to a method for the production of a device having osteoinductive and osteoconductive properties in vivo. The invention encompasses a pharmaceutical composition comprising the device of the invention or a device which is obtainable by the method of the invention and relates to the use of said device for the preparation of a pharmaceutical composition to be used for bone augmentation, for treating bone defects, for treating degenerative and traumatic disc disease, for treating bone dehiscence or to be used for sinus floor elevation. Finally, the invention relates to a kit comprising the device of the invention or a device which is obtainable by the method of the invention.

La présente invention concerne un dispositif doté de propriétés ostéoinductives et ostéoconductrices in vivo comprenant un support contenant du phosphate de calcium et une protéine ostéoinductive, ledit support étant recouvert de cette protéine de manière homogène. De plus, cette invention a trait à un procédé de production d'un dispositif pourvu de propriétés ostéoinductives et ostéconductrices in vivo, ainsi qu'à une composition pharmaceutique. Ledit dispositif de l'invention ou un dispositif qu'on peut obtenir au moyen du procédé de l'invention peut être utilisé dans la préparation d'une composition pharmaceutique destinée à une croissance osseuse, dans le traitement des déficits osseux, de la discopathie dégénérative et traumatique, la déhiscence osseuse ou dans l'élévation du plancher du sinus. Enfin, ladite invention a pour objet un kit comprenant le dispositif de l'invention ou un dispositif qu'on peut obtenir par le procédé susmentionné.

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