C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) C07K 14/47 (2006.01) C12N 15/63 (2006.01) C12Q 1/02 (2006.01)
Patent
CA 2488006
This invention relates to human chondrocyte activity (growth)/differentiation/production of extracellular matrix) and to the effect of Sox9transcription factor and Colt enhancer as a measure for such activity. It also relates to a chimeric cell and assay utilizing such cell useful in predicting the effect of sample compounds on chondrocyte activity as measured by Sox9 and Colt expression/activity.
L'invention concerne l'activité du chondrocyte humain (croissance/différentiation/production de matrice extracellulaire) et l'effet du facteur de transcription Sox9 et de l'amplificateur Colt utilisés comme mesure de cette activité. L'invention concerne également une cellule chimérique et un dosage utilisant ladite cellule servant à prédire l'effet de composés d'échantillon sur l'activité du chondrocyte telle que mesurée au moyen de l'expression/activité de Sox9 et de Colt.
Buckbinder Leonard
Schaefer Jean Frances
Pfizer Products Inc.
Smart & Biggar
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