A human cytotoxic t-lymphocyte epitope and its agonist...

Details A human cytotoxic t-lymphocyte epitope and its agonist... A human cytotoxic t-lymphocyte epitope and its agonist...

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 39/00 (2006.01) A61P 35/00 (2006.01) A61P 37/04 (2006.01) C07K 14/705 (2006.01) C12N 15/10 (2006.01) C12N 15/85 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2547635

Novel MUC-1 epitopes outside the VNTR region are identified. In addition, the first agonist epitope of MUC-1 is described. The employment of agonist epitopes in peptide, protein and vector-based vaccine may well aid in the development of effective vaccines for a range of human cancers.

Selon l'invention, de nouveaux épitopes de MUC-1 situés à l'extérieur de la région VNTR sont identifiés. De plus, le premier épitope agoniste de MUC-1 est décrit. L'utilisation d'épitopes agonistes dans des vaccins à base de peptides, de protéines et de vecteurs peut contribuer au développement de vaccins efficaces pour une pluralité de cancers humains.

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