A human edg-2 receptor homolog

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) A61K 31/70 (2006.01) A61K 38/17 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2224799

The present invention provides nucleic acid and amino acid sequences that identify and encode a novel EDG-2 receptor homolog (hedg) expressed in human rheumatoid synovium. The present invention also provides for probes for the detection of nucleotide sequences encoding of HEDG or HEDG-like molecules, antisense molecules to the nucleotide sequences which encode HEDG, diagnostic tests based on HEDG encoding nucleic acid molecules, genetically engineered expression vectors and host cells for the production of purified HEDG, antibodies capable of binding specifically to HEDG, and antagonists and inhibitors with specific binding activity for the polypeptide HEDG.

L'invention concerne des séquences nucléotidiques et d'acides aminés identifiant et codant un nouvel homologue du récepteur de EDG-2 (hedg) exprimé dans la synoviale rhumatoïde de l'homme. L'invention concerne également des sondes de détection de séquences nucléotidiques codant des molécules de HEDG ou semblables à HEDG, des molécules antisens par rapport au séquences nucléotidiques codant HEDG, des essais diagnostiques à base de HEDG codant des molécules d'acide nucléique, des vecteur d'expression obtenus par génie génétique et des cellules hôtes servant à produire HEDG purifié, des anticorps capables de se fixer spécifiquement à HEDG, ainsi que des antagonistes et des inhibiteurs possédant une activité de fixation spécifique au polypeptide HEDG.

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