A human gene over-expressing animal and test methods using...

A - Human Necessities – 01 – K

Patent

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Details

A01K 67/027 (2006.01) A61K 45/00 (2006.01) A61P 3/04 (2006.01) A61P 25/20 (2006.01) A61P 37/08 (2006.01) A61P 43/00 (2006.01) C12N 9/90 (2006.01) C12N 15/52 (2006.01) C12N 15/85 (2006.01) G01N 33/15 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2388227

An animal with the mass expression of a human gene which is a non-human animal obtained through the ontogenesis of a totipotent cell of a non-human animal having a human hematopoietic prostaglandin D2 synthase gene transferred thereinto or its offspring, characterized by carrying the above-described gene in its somatic cell chromosome and expressing human prostaglandin D2 synthase on a mass scale; and a method of testing the activities in individuals of candidates for anti-allergic drugs, sleep-controlling drugs and candidates for antiobestics by using the above animal.

L'invention concerne un animal exprimant un gène humain à grande échelle, lequel animal est un animal non humain obtenu par l'ontogénèse d'une cellule multipotente d'un animal non humain dans lequel on a transféré un gène de prostaglandine D¿2? synthase hématopoïétique humaine ou sa descendance. L'animal selon l'invention est caractérisé en ce qu'il est porteur du gène décrit ci-dessus au niveau du chromosome de sa cellule somatique et en ce qu'il exprime la prostaglandine D¿2? synthase humaine à grande échelle. L'invention concerne également un procédé permettant de tester, chez des individus, l'activité d'antiallergiques candidats, de régulateurs du sommeil, et de médicaments candidats contre l'obésité, lequel procédé repose sur l'utilisation dudit animal.

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