A human homologue of the dbf4/ask1 protein, nucleic acids,...

Details A human homologue of the dbf4/ask1 protein, nucleic acids,... A human homologue of the dbf4/ask1 protein, nucleic acids,...

C - Chemistry, Metallurgy

12

N

C12N 15/54 (2006.01) C07H 21/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 5/10 (2006.01) C12N 15/11 (2006.01) C12N 15/12 (2006.01) C12N 15/66 (2006.01) C12P 21/00 (2006.01)

Patent

CA 2412663

The present invention provides a human polypeptide homolog of DBF4/ASK1 and polynucleotides which identify and encode DRF1. In addition, the invention provides expression vectors, host cells and methods for its production. The invention also provides methods for the identification of DRF1 or DRF1- containing complex agonists/antagonists, useful for the treatment of human diseases and conditions.

L'invention concerne un homologue polypeptidique humain de DBF4/ASK1 et des polynucléotides permettant d'identifier et de coder DRF1. Elle concerne aussi des vecteurs d'expression, des cellules hôtes et des procédés de production de cet homologue. Elle concerne enfin des méthodes d'identification d'agonistes/antagonistes complexes contenant DRF1 ou DRF1, utiles dans le traitement de troubles et de maladies humaines.

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