A human kunitz-type protease inhibitor variant

Details A human kunitz-type protease inhibitor variant A human kunitz-type protease inhibitor variant

C - Chemistry, Metallurgy

12

N

C12N 15/15 (2006.01) A61K 38/57 (2006.01) C07K 14/81 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2127250

2127250 9314120 PCTABS00024 A variant of human Kunitz-type protease inhibitor domain III of tissue factor protease inhibitor (TFPI), the variant comprising the amino acid sequence (I) wherein X1 represents H or 1-5 naturally occurring amino acid residues except Cys, X2-X15 each independently represents a naturally occurring amino acid residue, and X16 represents OH or 1-5 naturally occurring amino acid residues except Cys, with the proviso that at least one of the amino acid residues X1-X16 is different from the corresponding amino acid residue of the native sequence.

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