A human nuclear protein having a ww domain and a...

Details A human nuclear protein having a ww domain and a... A human nuclear protein having a ww domain and a...

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 1/15 (2006.01) C12N 1/19 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01)

Patent

CA 2360530

This invention provides an isolated and purified human nuclear protein comprising the amino acid sequence of SEQ ID NO: 1, a polynucleotide encoding this protein, and an antibody against this protein. The protein and antibody of this invention are useful for diagnosis and therapy of morbid states such as cancers. This polynucleotide can be used to obtain the present protein in a large amount. By screening a low-molecular compound binding to the present protein, a new type of pharmaceutical preparation such as antitumor agent can be searched for.

Cette invention a trait à une nucléoprotéine humaine purifiée contenant la séquence aminoacide SEQ ID N DEG 1, à un polynucléotide codant cette protéine ainsi qu'à un anticorps contre cette protéine. Cette protéine et cet anticorps se révèlent des plus utiles en matière de diagnostic et de traitement de condition pathogènes du cancer, etc. Il est possible d'utiliser le polynucléotide susmentionné aux fins de l'obtention à grande échelle de cette protéine. On peut, en effectuant un criblage d'un composé de faible poids moléculaire se fixant à cette protéine, faire une recherche relative à des médicaments d'un nouveau type (agents antitumoraux, etc.).

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