A human protein tyrosine kinase

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/54 (2006.01) A61K 38/45 (2006.01) C07K 16/40 (2006.01) C12N 9/12 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2266424

The present invention provides a novel protein tyrosine kinase (HPTYK) and polynucleotides which identify and encode HPTYK. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding HPTYK and a method for producing HPTYK. The invention also provides pharmaceutical compositions containing HPTYK or antagonists to HPTYK, and for the use of these compositions in the treatment of diseases associated with the expression of HPTYK. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding HPTYK for the treatment of diseases associated with the expression of HPTYK. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, to hybridize to the genomic sequence or transcripts of polynucleotides encoding HPTYK or antibodies which specifically bind to HPTYK.

La présente invention concerne une nouvelle protéine tyrosine kinase (HPTYK) et des polynucléotides qui identifient et codent HPTYK. L'invention concerne, également, des vecteurs d'expression obtenus par génie génétique et des cellules hôtes comprenant les séquences d'acide nucléique codant HPTYK et un procédé de production de HPTYK. L'invention, concerne, également des compositions pharmaceutiques contenant HPTYK ou des antagonistes de HPTYK et l'utilisation de ces compositions dans le traitement de maladies associées à l'expression de HPTYK. L'invention concerne, en outre, l'utilisation de molécules antisens pour des polynucléotides codant HPTYK pour le traitement de maladies associées à l'expression de HPTYK. L'invention concerne, enfin, des analyses diagnostiques utilisant le polynucléotide ou des fragments ou le complément dudit polynucléotide pour hybrider la séquence génomique ou des produits de transcription des polynucléotides codant HPTYK ou des anticorps liés spécifiquement à HPTH.

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