A library of phylogenetically related sequences

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 14/435 (2006.01) C40B 40/10 (2006.01) C40B 50/02 (2006.01) C40B 50/06 (2006.01)

Patent

CA 2527317

The invention includes a method of assaying phylogenetically related sequences and generating a set of possible nucleic acid or amino acid sequence combinations. Sequences are analyzed to create an alignment and a set of phylogenetically related sequences are selected. The observed residue(s) or indel(s) occupying each position in the alignment of the selected phylogenetically related sequences are identified and this information is used to generate a set of sequence combinations, wherein the set of possible sequence combinations (nucleic acid or polypeptide) is composed of the union of the observed residues or indels identified at each position.

L'invention se rapporte à un procédé de dosage de séquences phylogénétiquement associées et de génération de combinaisons possibles de séquences d'acide nucléique ou d'acide aminé. Des séquences qui sont analysées afin de créer un alignement et un ensemble de séquences phylogénétiquement associées sont sélectionnées. Les résidus ou les suppressions/insertions (<= indels >=) occupant chaque position de l'alignement des séquences phylogénétiquement associées sélectionnées sont identifiés et cette information permet de générer un ensemble de combinaisons de séquences, l'ensemble de combinaisons de séquences possibles (acide nucléique ou polypeptide) étant composé de la réunion des résidus ou indels observés et identifiés à chaque position.

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