A lotion comprising a tricyclic macrolide

Details A lotion comprising a tricyclic macrolide A lotion comprising a tricyclic macrolide

A - Human Necessities

61

K

A61K 31/7052 (2006.01) A61K 9/10 (2006.01) A61K 31/407 (2006.01) A61K 31/436 (2006.01) A61K 31/55 (2006.01) A61K 31/70 (2006.01) A61K 31/706 (2006.01) A61K 47/00 (2006.01) A61P 17/00 (2006.01) A61P 29/00 (2006.01) A61K 47/10 (2006.01) A61K 47/14 (2006.01) A61K 47/32 (2006.01) A61K 47/44 (2006.01)

Patent

CA 2164838

A lotion comprising a tricyclic compound represented by 17-allyl-1,14-dihydroxy-12-[2-(4--hydroxy-3-methoxycyclohexyl)-1-methylvinyl]- 23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4--azatricyclo[22.3.1.0 4.9]octacos-18-ene-2,3,10,16-tetrone or a pharmaceutically acceptable salt thereof, a dissolution/absorption promoter, a liquid medium, and optionally an emulsifying agent or a mixture thereof with a thickening agent. The lotion is stable and excellent in absorbability, scarcely irritates the skin, and can be sustainedly released. It is useful for treating and preventing inflammatory and proliferative dermatoses and immunologically mediated skin diseases.

Lotion renfermant un composé tricyclique représenté par 17-alyl-1,14-dihydroxy-12-[2-(4-hydroxy-3-méthoxycyclohexyl)-1-méthylvinyl]-23,25-diméthoxy-13,19,21,27-tétraméthyl-11,28-dioxa-4-azatricyclo[22.3.1.0<4,9>]octaco-18-ène-2,3,10,16-tétrone ou sel pharmaceutiquement acceptable de ce composé, promoteur de dissolution ou d'absorption, milieu liquide et facultativement agent émulsifiant ou mélange d'un tel agent avec un agent épaississant. Cette lotion est stable, d'une excellente aptitude à l'absorption, n'a pas tendance à irriter la peau et peut faire l'objet d'une administration à libération prolongée. Elle est utile pour le traitement ou la prévention des dermatoses inflammatoires et proliférantes et des maladies de la peau à médiation immunologique.

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