C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/0783 (2010.01) A61K 35/14 (2006.01) A61K 39/00 (2006.01) A61K 39/12 (2006.01) C12N 5/10 (2006.01)
Patent
CA 2505379
The present invention relates to the production of a population of virus- specific CTLs in which the population contains an anti-virus specific gene expression construct. This population can be combined with a population of CD4+ T lymphocytes or a population of CD34+ hematopoietic progenitor cells and one or more of these populations of cells can be delivered to an autologous virus-positive individual. The present invention also relates to therapeutic cell products and to methods of treating diseases, particularly infectious diseases.
L'invention concerne la production d'une population de lymphocytes T cytotoxiques spécifiques d'un virus, ladite population contenant une construction d'expression génique spécifique d'un anti-virus. Cette population peut être combinée avec une population de lymphocytes CD4+ T ou une population de cellules progénitrices hématopoïétiques CD34+, et une ou plusieurs de ces populations cellulaires peuvent être distribuées à un individu positif à un virus autologue. L'invention concerne également des produits cellulaires thérapeutiques et des méthodes permettant de traiter des maladies, en particulier, des maladies infectieuses.
Fanning Gregory Charles
Pond Susan Margaret
Symonds Geoffrey Philip
Gowling Lafleur Henderson Llp
Johnson & Johnson Research Pty Limited
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