A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/166 (2006.01) A61P 19/02 (2006.01) A61P 43/00 (2006.01)
Patent
CA 2456965
A remedy and/or preventive for arthrosis deformans which contains as the active ingredient either a hydroxamic acid derivative represented by the formula (I): (I) [wherein R1 represents hydrogen or C1-8 alkyl optionally substituted by -OR2 (R2 represents hydrogen, C1-8 alkyl, benzyl, or C1-8 alkyl substituted by C1-8 alkoxy)] or a nontoxic salt thereof. The compounds have matrix metalloproteinase inhibitory activity.
L'invention concerne un agent curatif et/ou préventif pour arthrosis deformans, contenant comme ingrédient actif soit un dérivé d'acide hydroxamique représenté par la formule (I) [dans laquelle R?1¿ représente de l'hydrogène ou C¿1-8 ?alkyle éventuellement substitué par -OR?2¿¿ ?(R?2¿ représente de l'hydrogène, C¿1-8? alkyle, benzyle ou C¿1-8 ?alkyle substitué par C¿1-8 ? alkoxy)], soit un sel non toxique de celui-ci. Ces composés présentent une activité d'inhibition de la métalloprotéinase matricielle.
Maeda Yoshizo
Ogawa Koji
Yamashita Kazunori
Ono Pharmaceutical Co. Ltd.
Riches Mckenzie & Herbert Llp
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