C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 31/70 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) C07K 14/52 (2006.01) C07K 14/705 (2006.01) C07K 14/71 (2006.01) C07K 16/28 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2231017
FRAZZLED polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing FRAZZLED polypeptides and polynucleotides in the design of protocols for the treatment of chronic and acute inflammation, arthritis, osteoarthritis, septicemia, autoimmune diseases (e.g., inflammatory bowel disease, psoriasis), transplant rejection, graft vs. host disease, infection, stroke, ischemia, acute respiratory disease syndrome, renal disorders, restenosis, brain injury, AIDS, metabolic and other bone diseases (e.g., osteoporosis), cancer (e.g., lymphoproliferative disorders), atherosclerosis, and Alzheimer's disease, among others, and diagnostic assays for such conditions.
Polypeptides et polynucléotides FRAZZLED et méthodes pour produire ces polypeptides par les techniques d'ADN recombinant. Sont également décrites des méthodes pour utiliser les polypeptides et polynucléotides FRAZZLED dans la conception de protocoles pour traiter les inflammations chroniques et aiguës, l'arthrite, l'arthrose, la septicémie, les maladies autoimmunes (p. ex. les maladies intestinales inflammatoires, le psoriasis), les rejets de greffes, les réactions du greffon contre l'hôte, les infections, les accidents vasculaires cérébraux, l'ischémie, les atteintes respiratoires aiguës, les troubles rénaux, la resténose, les lésions cérébrales, le sida, les affections métaboliques et autres maladies des os (p. ex. l'ostéoporose), les cancers (p. ex. les affections lymphoprolifératives), l'athérosclérose et la maladie d'Alzheimer, entre autres affections, de même que des épreuves diagnostiques pour déceler ces affections.
James Ian Edward
Kumar Sanjay
Lark Michael William
Gowling Lafleur Henderson Llp
Smithkline Beecham Corporation
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