A membrane or matrix for controlling the permeation rate of...

C - Chemistry – Metallurgy – 08 – L

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Details

C08L 83/12 (2006.01) A61K 9/20 (2006.01) A61K 9/58 (2006.01) C08G 77/46 (2006.01) A61K 9/00 (2006.01)

Patent

CA 2336149

The invention relates to a membrane or matrix for controlling the permeation rate of a drug, wherein said membrane or matrix comprises a siloxane-based elastomer composition which comprises at least one elastomer and possibly a non-crosslinked polymer. The elastomer composition comprises poly(alkylene oxide) groups, and the poly(alkylene oxide) groups are present in the elastomer or the polymer as alkoxy-terminated grafts of polysiloxane units, or as blocks, the said grafts or blocks being linked to the polysiloxane units by silicon-carbon bonds, or as a mixture of these forms. The invention also relates to methods for the preparation of the elastomer composition to be used in said membrane or matrix.

La présente invention concerne une membrane ou une matrice destinée à réguler la vitesse de perméation d'un médicament, ladite membrane ou matrice comprenant une composition d'élastomère à base de siloxane qui contient au moins un élastomère et éventuellement un polymère non réticulé. La composition d'élastomère renferme des groupes poly(alkylène oxyde) qui sont présents dans l'élastomère ou le polymère sous forme de greffes à terminaison alcoxy d'unités polysiloxane, ou sous forme de blocs, lesdites greffes ou lesdits blocs étant liés aux unités polysiloxane par des liaisons silicium-carbone, ou bien sous forme d'un mélange de ces formes. L'invention concerne également des procédés de préparation de la composition d'élastomère destinée à être utilisée dans ladite membrane ou matrice.

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