A method for altering insulin pharmacokinetics

A - Human Necessities – 61 – M

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A61M 5/46 (2006.01) A61K 38/28 (2006.01)

Patent

CA 2524444

The present invention relates to methods for administration of insulin into the intradermal compartment of subject's skin, preferably to the dermal vasculature of the intradermal compartment. The methods of the present invention enhance the pharmacokinetic and pharmacodynamic parameters of insulin delivery and effectively result in a superior clinical efficacy in the treatment and/or prevention of diabetes mellitus. The methods of the instant invention provide an improved glycemic control of both non-fasting (i.e., post-prandial) and fasting blood glucose levels and thus have an enhanced therapeutic efficacy in treatment, prevention and/or management of diabetes relative to traditional methods of insulin delivery, including subcutaneous insulin delivery.

La présente invention concerne des méthodes d'administration d'insuline dans le compartiment intradermique de la peau d'un patient, de préférence dans le système vasculaire dermique du compartiment intradermique. Les méthodes de la présente invention améliorent les paramètres pharmacocinétiques et pharmacodynamiques de l'injection d'insuline et aboutissent effectivement à une efficacité clinique supérieure dans le traitement et/ou la prévention du diabète sucré. Lesdites méthodes permettent une régulation glycémique améliorée de glycémies à jeun et non à jeun (c.-à-d. post-prandiale) et possèdent ainsi une efficacité thérapeutique améliorée dans le traitement, la prévention et/ou la gestion du diabète par rapport à des méthodes d'injection d'insuline classiques, y compris l'injection sous-cutanée d'insuline.

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