A method for characterizing the efficacy of an agent...

G - Physics – 01 – N

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G01N 33/50 (2006.01)

Patent

CA 2596082

Generally, the method for characterizing the efficacy of an agent targeting a primary cystic fibrosis defect comprises measuring a change in the status of lung infection in a sample population of subjects administered the agent in comparison to a control sample population of subjects; wherein the subjects in the sample population and the control sample population have the primary cystic fibrosis defect and are uninfected before the agent is administered; wherein a beneficial change in the presence of lung infection in the sample population in comparison to the control sample population is indicative of a treatment effect; and wherein the agent lacks intrinsic antibiotic activity.

En général, la méthode de caractérisation de l'efficacité d'un agent ciblant un défaut de fibrose cystique consiste à mesurer un changement de l'état d'une infection pulmonaire dans un échantillon d'individus au sein de la population à qui l'agent a été administré en comparaison avec un échantillon témoin d'individus au sein de cette même population. Les individus provenant de ces deux échantillons présentent le défaut de fibrose cystique primaire et ne sont pas infectés, avant l'administration de l'agent. Un changement bénéfique en présence d'une infection pulmonaire de l'échantillon d'individus en comparaison avec l'échantillon témoin d'individus indique un effet du traitement et l'agent présente un manque d'activité intrinsèque antibiotique.

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