A method for detecting protein inhibitors and ligands

C - Chemistry – Metallurgy – 12 – Q

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C12Q 1/37 (2006.01) A61K 31/435 (2006.01) C07D 211/70 (2006.01)

Patent

CA 2411436

The invention relates to a method for identifying inhibitors or ligands for binding domains. The inventive method comprises using a protein that has at least one catalytic domain, incubating it with a marker substrate that binds to the catalytic domain of the protein and reacts therewith, with a substrate that can reversibly bind to the catalytic domain and to the binding domain, and with the inhibitor, and detecting whether the protein reacts with the marker substrate.

L'invention concerne un procédé d'identification d'inhibiteurs ou de ligand pour des domaines de liaison. Selon ledit procédé, on utilise une protéine contenant au moins un domaine catalytique et au moins un domaine de liaison, et on la fait incuber avec un substrat marqueur qui se lie au domaine catalytique de cette protéine et réagit avec elle, avec un substrat qui peut se lier de façon réversible au domaine catalytique et au domaine de liaison, et avec l'inhibiteur, puis on détecte si la protéine réagit avec le substrat marqueur.

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