A method for determining the biological activity of defibrotide

Details A method for determining the biological activity of defibrotide A method for determining the biological activity of defibrotide

C - Chemistry, Metallurgy

12

Q

C12Q 1/37 (2006.01) C12Q 1/56 (2006.01) G01N 33/48 (2006.01)

Patent

CA 2468877

An enzymatic method for determining the biological activity of defibrotide is described. The method, which is based on the capacity of defibrotide to potentiate the enzymatic activity of plasmin, comprises the steps of: a) bringing into contact defibrotide, plasmin and a substrate specific for the plasmin which, by reaction with the plasmin, provides a measurable product and b) measuring the amount of product formed at successive times.

L'invention concerne une méthode enzymatique de mesure de l'activité biologique d'un défibrotide. La méthode, qui est fondée sur la capacité du défibrotide à déclencher l'activité enzymatique de la plasmine, consiste a) à mettre en contact le défibrotide, la plasmine et un substrat spécifique pour la plasmine qui réagit avec la plasmine et fournit un produit mesurable et b) à mesurer, à intervalles réguliers, la quantité de produit formé.

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